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For the first time, a one-off flight will go to New York from East Midlands Airport.
EMA hope it'll encourage other carriers to make transatlantic journeys from the region.
Jet2 will leave for New York's Newark Airport in November.
Managing Director at East Midlands Airport Brad Miller:
"Securing a transatlantic route for the East Midlands is something we're committed to achieving.
"The special departure, will demonstrate the support the region has for transatlantic flights and hopefully play a significant part in securing a long term operation from the base."