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24 August 2015, 07:26 | Updated: 30 March 2016, 13:50
It happened in the early hours of yesterday between 2am and 3.30am.
The woman had been at the O2 Academy on Westgate Road with friends and she was raped after she left the venue and was walking along the top of Pink Lane at the Waterloo Street junction.
The offender is described as a white man, approximately 6 feet tall. After the rape the victim sought help.
The investigation into the incident is underway and officers are in the area carrying out enquiries. Specially trained officers are working with the woman to offer her support.
Detective Sergeant Tanya Robinson said:
"This is clearly a distressing incident for the woman and we have specially trained officers ensuring she has the support she needs.
"We're carrying out enquiries into the incident and would ask anyone who thinks they have information that could help to get in contact.
"We'd also like to hear from anyone else who was in this area around the Pink Lane, Waterloo Street at the relevant time and who may have seen this woman or her attacker.
"There may be other people who had left the O2 Academy at around the same time and may have also followed this route.They could have important information that can help with out enquiries and help identify and trace the person responsible."
Police will be carrying out regular patrols throughout the city centre to offer reassurance to those in the area.