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30 May 2012, 16:34 | Updated: 30 May 2012, 16:41
The R&B star will be aiming to take the chart summit away from Eurovision winner Loreen.
Usher's brand new single 'Scream' is set to challenge for the Vodafone Big Top 40 number one this week.
The 'Climax' star will face strong challenges from Rudimental with 'Feel The Love' as well as DJ Fresh's Dizzee Rascal collaboration 'The Power'.
The current number one spot is occupied by Eurovision Song Contest champion Loreen from Sweden who claimed the position with her single 'Euphoria' last weekend.
Elsewhere on the chart, Lawson will be challenging the number one position with their debut single 'When She Was Mine' and former chart topper 'We Are Young' from Fun could also make it back to the top.
You can hear the Vodafone Big Top 40 with Rich and Kat every Sunday from 4-7pm.