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The Stone Roses will headline on the main stage on the Friday.
Meanwhile rock act Bon Jovi are to close the show on the Sunday.
It will be their only UK festival performance of 2013.
Frontman Jon Bon Jovi said his group was `honoured' to playing.
''The Isle of Wight Festival is legendary and we're excited to join in the long tradition of rock'n'roll history,'' he said.
''This will mark our first visit to the island and I expect it will prove to be a highlight of our tour and of 2013.''
Promoter John Giddings said: ''I can't imagine a better rock band with more hits to close our Sunday night.''
The headline act for the Saturday hasn't been announced yet.
This year, artists such as Bruce Springsteen, Pearl Jam, Tom Petty, Noel Gallagher and Jessie J were among the big-name performers.
There are more details about the event, www.isleofwightfestival.com.