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Police were called to Tatton Road, Ordsall, on Sunday morning following reports a boy had been shot.
Officers discovered a 17-year-old boy with gunshot wounds to his leg and an 18-year-old man, also with a gunshot wound to the leg.
Both have been taken to hospital and their injuries are not thought to be life threatening.
Lee Erdman, 37, was shot dead in The Wellington pub in Regent Road on 10 September.
A £50, 000 reward is offered for information leading to his killer.
A police spokesman confirmed officers were investigating whether the shootings were connected.
Anyone with information is asked to call the Greater Manchester Police Major Incident Team on 0161 856 1722 or the independent charity Crimestoppers, anonymously, on 0800 555 111.