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1 March 2012, 09:52
The singer was joined by her mother as she spoke to Harvard University students.
Lady Gaga has called on those with "revolutionary potential" to help make the world a better place.
The singer was speaking at the launch of her Born This Way Foundation at Harvard University in America.
Joined by her mother and the foundation's co-founder Cynthia Germanotta and TV host Oprah Winfrey, Lady Gaga told more than 1,100 students to "challenge meanness and cruelty".
She said: "I believe that if you have revolutionary potential, you must make the world a better place and use it."
Wearing a black statement outfit, Lady Gaga also said she wished there was a law for kindness and paid tribute to her mother, who had inspired her to establish the foundation.
"She is the sole reason that I am here today. She has always believed in me," Lady Gaga said. "She has always been my support, and she makes me want to inject that sense of family and support into the world."
The organisation, which takes its name from the singer's album and single of the same name, is designed to inspire and empower young people.
Check out a video of Lady Gaga launching her foundation below: