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2 December 2011, 15:04
The 'Rolling In The Deep' singer is bookies top choice to take the award at the February event.
Adele is the bookies favourite to win the Album Of The Year crown at next year's Grammy Awards.
The 'Set Fire To The Rain' singer is at odds as low as 11/8 at Ladbrokes with closest rivals Foo Fighters and Bruno Mars at 3/1.
A spokesperson for the bookmakers told MTV: "Adele's taken America by storm, and she now looks set to clean up at the Grammys. British punters will be rolling in it if she does the business."
Adele is nominated for a total of six awards at the ceremony including Song Of The Year and Record Of The Year.
You can view a list of the odds for the Album Of The Year Award below:
Adele, '21' – 11/8
Bruno Mars, 'Doo Wops & Hooligans' – 3/1
Foo Fighters, 'Wasting Light' - 3/1
Lady Gaga, 'Born This Way' - 6/1
Rihanna, 'Loud' - 10/1